Lower Incidence of Hypoglycemia With Angiotensin Receptor Blocker Versus ACE Inhibitor Therapy in People With or Without Diabetes

Israel Khanimov; Boris Zingerman; Benaya Rozen-Zvi; Mordechai Shimonov; Eyal Leibovitz

doi:10.2337/cd23-0039

Lower Incidence of Hypoglycemia With Angiotensin Receptor Blocker Versus ACE Inhibitor Therapy in People With or Without Diabetes

Clin Diabetes. 2024 Spring;42(2):300-307. doi: 10.2337/cd23-0039. Epub 2024 Jan 12.

Authors

Israel Khanimov¹, Boris Zingerman², Benaya Rozen-Zvi², Mordechai Shimonov³, Eyal Leibovitz^{4

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Affiliations

¹ Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
² Department of Nephrology at the Hasharon Campus, Rabin Medical Center, Petah Tikva, Israel.
³ Department of Surgery A, Edith Wolfson Medical Center, Holon, Israel.
⁴ Department of Internal Medicine A, Yoseftal Medical Center, Eilat, Israel.
⁵ Research Unit of the Surgical Division, Edith Wolfson Medical Center, Holon, Israel.
⁶ The Adelson School of Medicine, Ariel University, Ariel, Israel.

PMID: 38694239
PMCID: PMC11060618 (available on 2025-03-01)
DOI: 10.2337/cd23-0039

Abstract

This article describes a study examining the association between treatment with ACE inhibitors or angiotensin receptor blockers (ARBs) and incident hypoglycemia in patients with or without diabetes who were admitted to the internal medicine departments of a tertiary hospital in the Tel Aviv district of Israel. The authors found that treatment with ARBs, but not ACE inhibitors, compared with treatment with neither, was associated with a reduced risk of hypoglycemia regardless of diabetes status.