Digitally-enabled, person-centred care (PCC) in allergen immunotherapy: An ARIA-EAACI Position Paper

Oliver Pfaar; Bernardo Sousa-Pinto; Nikolaos G Papadopoulos; Désirée E Larenas-Linnemann; Michal Ordak; Maria J Torres; Ralph Mösges; Ludger Klimek; Torsten Zuberbier; Paolo M Matricardi; Uwe E Berger; Markus Berger; Stephanie Dramburg; Vera Mahler; Sanna K Toppila-Salmi; Karl-Christian Bergmann; Markus Ollert; Salvatore Tripodi; Marek Jutel; Ioana Agache; Ibon Eguiluz-Gracia; G Walter Canonica; Cezmi A Akdis; Milena Sokolowska; Mikhail Sofiev; Mohamed H Shamji; Wienczyslawa Czarlewski; Joao A Fonseca; Anna Bedbrook; Jean Bousquet

doi:10.1111/all.16135

Digitally-enabled, person-centred care (PCC) in allergen immunotherapy: An ARIA-EAACI Position Paper

Allergy. 2024 Aug;79(8):2037-2050. doi: 10.1111/all.16135. Epub 2024 May 3.

Authors

Oliver Pfaar¹, Bernardo Sousa-Pinto^{2

3}, Nikolaos G Papadopoulos⁴, Désirée E Larenas-Linnemann⁵, Michal Ordak⁶, Maria J Torres⁷, Ralph Mösges^{8

9}, Ludger Klimek^{10

11}, Torsten Zuberbier^{12

13}, Paolo M Matricardi^{12

13

14}, Uwe E Berger^{15

16}, Markus Berger^{15

16

17}, Stephanie Dramburg¹⁴, Vera Mahler¹⁸, Sanna K Toppila-Salmi^{19

20}, Karl-Christian Bergmann^{12

13}, Markus Ollert^{21

22}, Salvatore Tripodi²³, Marek Jutel^{24

25}, Ioana Agache²⁶, Ibon Eguiluz-Gracia⁷, G Walter Canonica^{27

28}, Cezmi A Akdis²⁹, Milena Sokolowska²⁹, Mikhail Sofiev³⁰, Mohamed H Shamji^{31

32}, Wienczyslawa Czarlewski^{33

34}, Joao A Fonseca^{2

3}, Anna Bedbrook^{34

35}, Jean Bousquet^{12

13

34

35}

Affiliations

¹ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
² MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
³ CINTESIS@RISE-Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.
⁴ Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
⁵ Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
⁶ Department of Pharmacotherapy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.
⁷ Allergy Unit, Hospital Regional Universitario de Malaga, IBIMA-Plataforma BIONAND, Universidad de Malaga, RICORS de Enfermedades Inflamatorias, Malaga, Spain.
⁸ Institute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany.
⁹ ClinCompetence Cologne GmbH, Cologne, Germany.
¹⁰ Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.
¹¹ Center for Rhinology and Allergology, Wiesbaden, Germany.
¹² Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
¹³ Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.
¹⁴ Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin - Berlin, Berlin, Germany.
¹⁵ Department of Botany, University of Innsbruck, Innsbruck, Austria.
¹⁶ European Aeroallergen Network (EAN), Vienna, Austria.
¹⁷ Department of Oto-Rhino-Laryngology, Klinik Hietzing, Wiener Gesundheitsverbund, Vienna, Austria.
¹⁸ Paul-Ehrlich-Institut, Langen, Germany.
¹⁹ Department of Otorhinolaryngology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
²⁰ Department of Allergy, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
²¹ Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
²² Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark.
²³ Allergy Unit, Policlinico Casilino, Roma, Italy.
²⁴ Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland.
²⁵ ALL-MED Medical Research Institute, Wroclaw, Poland.
²⁶ Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania.
²⁷ Department of Biomedical Sciences, Humanitas University, Milan, Italy.
²⁸ Asthma and Allergy Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
²⁹ Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
³⁰ Finnish Meteorological Institute (FMI), Helsinki, Finland.
³¹ National Heart and Lung Institute, Imperial College, London, UK.
³² NIHR Imperial Biomedical Research Centre, London, UK.
³³ Medical Consulting Czarlewski, Levallois, France.
³⁴ MASK-air, Montpellier, France.
³⁵ ARIA, Montpellier, France.

PMID: 38700063
DOI: 10.1111/all.16135

Abstract

In rhinitis and asthma, several mHealth apps have been developed but only a few have been validated. However, these apps have a high potential for improving person-centred care (PCC), especially in allergen immunotherapy (AIT). They can provide support in AIT initiation by selecting the appropriate patient and allergen shared decision-making. They can also help in (i) the evaluation of (early) efficacy, (ii) early and late stopping rules and (iii) the evaluation of (carried-over) efficacy after cessation of the treatment course. Future perspectives have been formulated in the first report of a joint task force (TF)-Allergic Rhinitis and Its Impact on Asthma (ARIA) and the European Academy of Allergy and Clinical Immunology (EAACI)-on digital biomarkers. The TF on AIT now aims to (i) outline the potential of the clinical applications of mHealth solutions, (ii) express their current limitations, (iii) make proposals regarding further developments for both clinical practice and scientific purpose and (iv) suggest which of the tools might best comply with the purpose of digitally-enabled PCC in AIT.

Keywords: AllergyMonitor®; MASK‐air®; allergen immunotherapy; allergy; digital biomarkers.

Publication types

Review

MeSH terms

Asthma / immunology
Asthma / therapy
Desensitization, Immunologic* / methods
Humans
Mobile Applications
Patient-Centered Care*
Rhinitis, Allergic / immunology
Rhinitis, Allergic / therapy
Telemedicine*

Abstract

Publication types

MeSH terms

Grants and funding