Keratosis Pilaris-Like Reaction Associated With Chromatin Remodeling Complex Inhibition in Uveal Melanoma

Riyad N H Seervai; Madison M Taylor; Ziba Rahbar; Sapna P Patel; Kelly C Nelson; Victor G Prieto; Jonathan L Curry

doi:10.1001/jamadermatol.2024.1137

Keratosis Pilaris-Like Reaction Associated With Chromatin Remodeling Complex Inhibition in Uveal Melanoma

JAMA Dermatol. 2024 Jun 1;160(6):682-685. doi: 10.1001/jamadermatol.2024.1137.

Authors

Riyad N H Seervai^{1

2

3}, Madison M Taylor^{4

5}, Ziba Rahbar⁶, Sapna P Patel⁷, Kelly C Nelson⁵, Victor G Prieto^{5

6}, Jonathan L Curry^{6

8}

Affiliations

¹ Department of Dermatology, Oregon Health and Science University, Portland.
² Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas.
³ Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, Texas.
⁴ John P. and Katherine G. McGovern Medical School, The University of Texas Health Science Center, Houston.
⁵ Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston.
⁶ Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston.
⁷ Departments of Melanoma Medical Oncology and Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston.
⁸ Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston.

PMID: 38717752
DOI: 10.1001/jamadermatol.2024.1137

No abstract available

Plain language summary

This case series describes a constellation of novel adverse reactions in 3 of 9 patients with uveal melanoma receiving treatment targeting activity of the Brahma-associated factor chromatin remodeling complex.

Publication types

Case Reports

MeSH terms

Abnormalities, Multiple
Chromatin Assembly and Disassembly
Darier Disease / diagnosis
Darier Disease / pathology
Eyebrows / abnormalities
Female
Humans
Male
Melanoma* / pathology
Middle Aged
Transcription Factors / genetics
Uveal Melanoma
Uveal Neoplasms* / genetics
Uveal Neoplasms* / pathology

Substances

Transcription Factors

Supplementary concepts

Burnett Schwartz Berberian syndrome