Dataset of weekly intra-treatment diffusion weighted imaging in head and neck cancer patients treated with MR-Linac

Dina M El-Habashy; Kareem A Wahid; Renjie He; Brigid McDonald; Samuel J Mulder; Yao Ding; Travis Salzillo; Stephen Y Lai; John Christodouleas; Alex Dresner; Jihong Wang; Mohamed A Naser; Clifton D Fuller; Abdallah Sherif Radwan Mohamed; Joint Head and Neck Radiation Therapy-MRI Development Cooperative

doi:10.1038/s41597-024-03217-z

Dataset of weekly intra-treatment diffusion weighted imaging in head and neck cancer patients treated with MR-Linac

Sci Data. 2024 May 11;11(1):487. doi: 10.1038/s41597-024-03217-z.

Authors

Dina M El-Habashy^{1

2}, Kareem A Wahid³, Renjie He³, Brigid McDonald³, Samuel J Mulder³, Yao Ding⁴, Travis Salzillo⁴, Stephen Y Lai^{3

5

6}, John Christodouleas⁷, Alex Dresner⁸, Jihong Wang⁴, Mohamed A Naser³, Clifton D Fuller⁹, Abdallah Sherif Radwan Mohamed^{10

11}; Joint Head and Neck Radiation Therapy-MRI Development Cooperative

Affiliations

¹ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [email protected].
² Department of Clinical Oncology and Nuclear Medicine, Menoufia University, Shebin Elkom, Egypt. [email protected].
³ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁴ Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁵ Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁶ Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁷ Elekta AB, Stockholm, Sweden.
⁸ Philips Healthcare MR Oncology, Cleveland, Ohio, USA.
⁹ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [email protected].
¹⁰ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [email protected].
¹¹ Department of Radiation Oncology, Baylor College of Medicine, Houston, TX, USA. [email protected].

Abstract

Radiation therapy (RT) is a crucial treatment for head and neck squamous cell carcinoma (HNSCC); however, it can have adverse effects on patients' long-term function and quality of life. Biomarkers that can predict tumor response to RT are being explored to personalize treatment and improve outcomes. While tissue and blood biomarkers have limitations, imaging biomarkers derived from magnetic resonance imaging (MRI) offer detailed information. The integration of MRI and a linear accelerator in the MR-Linac system allows for MR-guided radiation therapy (MRgRT), offering precise visualization and treatment delivery. This data descriptor offers a valuable repository for weekly intra-treatment diffusion-weighted imaging (DWI) data obtained from head and neck cancer patients. By analyzing the sequential DWI changes and their correlation with treatment response, as well as oncological and survival outcomes, the study provides valuable insights into the clinical implications of DWI in HNSCC.

Publication types

Dataset
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Diffusion Magnetic Resonance Imaging*
Head and Neck Neoplasms* / diagnostic imaging
Head and Neck Neoplasms* / radiotherapy
Humans
Particle Accelerators
Radiotherapy, Image-Guided
Squamous Cell Carcinoma of Head and Neck / diagnostic imaging
Squamous Cell Carcinoma of Head and Neck / radiotherapy

Abstract

Publication types

MeSH terms

Grants and funding