Empagliflozin Attenuates Arrhythmias in an iPSC-Based Model of Hypertrophic Cardiomyopathy

Circ Genom Precis Med. 2024 Jun;17(3):e004526. doi: 10.1161/CIRCGEN.123.004526. Epub 2024 May 16.

Jennifer Arthur Ataam^#^{1

2}, Nadjet Belbachir^#^{2

3}, Isaac Perea-Gil^#^{1

2}, Vittavat Termglinchan^{1

2}, Nirmal Vadgama^{1

2}, Priyanka Garg^{2

3}, Rohin Ramchandani^{1

2}, Alexandra A Gavidia^{1

2}, Santiago Roura^{4

5

6}, Carolina Gálvez-Montón^{4

5}, Joseph C Wu^{2

3}, Antoni Bayés-Genis^{4

5

7

8}, Ioannis Karakikes^{1

2}

¹ Department of Cardiothoracic Surgery (J.A.A., I.P.-G., V.T., N.V., R.R., A.A.G., I.K.), Stanford University School of Medicine, CA.
² Stanford Cardiovascular Institute (J.A.A., N.B., I.P.-G., V.T., N.V., P.G., R.R., A.A.G., J.C.W., I.K.), Stanford University School of Medicine, CA.
³ Department of Medicine (N.B., P.G., J.C.W.), Stanford University School of Medicine, CA.
⁴ Insuficiencia Cardiaca i Regeneració Cardiaca, Research Program, Germans Trias i Pujol Health Science Research Institute, Badalona, Spain (S.R., C.G.-M., A.B.-G.).
⁵ Centro de Investiogación en Red Cardiovascular, Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (S.R., C.G.-M., A.B.-G.).
⁶ Faculty of Medicine, University of Vic-Central University of Catalonia, Spain (S.R.).
⁷ Cardiology Service, Germans Trias i Pujol University Hospital, Badalona, Spain (A.B.-G.).
⁸ Department of Medicine, Universitat Autònoma de Barcelona, Spain (A.B.-G.).

^# Contributed equally.

No abstract available

Keywords: arrhythmias; cardiac; cardiomyopathy; drug repositioning; genetics; hypertrophic; myocytes; sodium-glucose transporter 2 inhibitors.

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