Wound colonization with methicillin-resistant Staphylococcus aureus and hypotheses about acquisition routes in rural health care settings in Sub-Saharan Africa: Perspective from a center devoted to the treatment of cutaneous neglected tropical diseases

Thomas Nicol; Charles Declerck; Morgane Le Gallo; Camille Bougeard; Akimat Habib; Périn Catraye; Ambroise Adeye; Alexandra Boccarossa; Vincent Dubée; Laurent Marsollier; Estelle Marion; Roch Christian Johnson; Matthieu Eveillard

doi:10.1016/j.ajic.2024.05.007

Wound colonization with methicillin-resistant Staphylococcus aureus and hypotheses about acquisition routes in rural health care settings in Sub-Saharan Africa: Perspective from a center devoted to the treatment of cutaneous neglected tropical diseases

Am J Infect Control. 2024 Aug;52(8):977-980. doi: 10.1016/j.ajic.2024.05.007. Epub 2024 May 18.

Authors

Affiliations

¹ Université Angers, Nantes Université, CHU Angers, Inserm, CNRS, INCIT, Angers, France; Laboratoire de Bactériologie, Département de Biologie des Agents Infectieux, CHU Angers, Angers, France.
² Service des Maladies Infectieuses et Tropicales, CHU Angers, Angers, France.
³ Pôle Biologie, CHU Angers, Angers, France.
⁴ Laboratoire de Bactériologie, Département de Biologie des Agents Infectieux, CHU Angers, Angers, France.
⁵ Centre de Diagnostic et de Traitement de la Lèpre et de l'Ulcère de Buruli - Raoul Follereau Foundation, Pobè, Benin.
⁶ Université Angers, Nantes Université, CHU Angers, Inserm, CNRS, INCIT, Angers, France.
⁷ Université Angers, Nantes Université, CHU Angers, Inserm, CNRS, INCIT, Angers, France; Service des Maladies Infectieuses et Tropicales, CHU Angers, Angers, France.
⁸ Centre de Diagnostic et de Traitement de la Lèpre et de l'Ulcère de Buruli - Raoul Follereau Foundation, Pobè, Benin; Centre Interfacultaire de Formation et de Recherche en Environnement pour le Développement Durable, Université d'Abomey-Calavi, Abomey-Calavi, Benin.
⁹ Université Angers, Nantes Université, CHU Angers, Inserm, CNRS, INCIT, Angers, France; Laboratoire de Bactériologie, Département de Biologie des Agents Infectieux, CHU Angers, Angers, France. Electronic address: [email protected].

PMID: 38763430
DOI: 10.1016/j.ajic.2024.05.007

Abstract

We identified a high prevalence (46.4%) of wound colonization with methicillin-resistant Staphylococcus aureus (MRSA) in patients hospitalized in a center devoted to the treatment of cutaneous tropical diseases in Benin. The proportion of MRSA among S aureus isolates was 54.3%. Thirty percent of these MRSA were identified in outpatients. The analysis of pulsed-field gel electrophoresis demonstrated an important diversity of strains but also identified 8 small clusters containing between 2 and 4 isolates suggesting cross-transmission.

Keywords: Clinical microbiology laboratory; Cross-transmission; Low resources; MRSA; Prevalence; Wounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Benin / epidemiology
Carrier State / epidemiology
Carrier State / microbiology
Child
Child, Preschool
Cross Infection / epidemiology
Cross Infection / microbiology
Electrophoresis, Gel, Pulsed-Field
Female
Humans
Infant
Male
Methicillin-Resistant Staphylococcus aureus* / isolation & purification
Middle Aged
Neglected Diseases / epidemiology
Neglected Diseases / microbiology
Prevalence
Rural Population*
Staphylococcal Infections* / drug therapy
Staphylococcal Infections* / epidemiology
Staphylococcal Infections* / microbiology
Staphylococcal Skin Infections / drug therapy
Staphylococcal Skin Infections / epidemiology
Staphylococcal Skin Infections / microbiology
Wound Infection / drug therapy
Wound Infection / epidemiology
Wound Infection / microbiology
Young Adult