WW domains: A globular NLS recognized by importin-α

J Cell Biol. 2024 Jun 3;223(6):e202405003. doi: 10.1083/jcb.202405003. Epub 2024 May 20.

Abstract

In this issue, the discovery by Yang et al. (https://doi.org/10.1083/jcb.202308013) that folded WW domains of YAP1 and other proteins bind to Impα introduces a new class of globular NLS, contrasting with the extensively studied linear NLS motifs. This finding underscores the versatility of importins in recognizing their cargo proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / chemistry
  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / metabolism
  • Humans
  • Nuclear Localization Signals* / metabolism
  • Protein Binding
  • Transcription Factors / chemistry
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • WW Domains / genetics
  • YAP-Signaling Proteins / metabolism
  • alpha Karyopherins / chemistry
  • alpha Karyopherins / genetics
  • alpha Karyopherins / metabolism

Substances

  • YAP1 protein, human