Myocardial Infarction and Coronary Anomalies in a 25-Year-Old Neurofibromatosis Type 1 Patient

Sebastiaan van Gelder; Paul F Teunissen; Lokien X van Nunen

doi:10.1016/j.jaccas.2024.102261

Myocardial Infarction and Coronary Anomalies in a 25-Year-Old Neurofibromatosis Type 1 Patient

JACC Case Rep. 2024 Apr 17;29(8):102261. doi: 10.1016/j.jaccas.2024.102261.

Authors

Sebastiaan van Gelder¹, Paul F Teunissen¹, Lokien X van Nunen¹

Affiliation

¹ Radboud University Medical Center, Department of Cardiology, Nijmegen, the Netherlands.

Abstract

A 25-year-old male with neurofibromatosis type 1 presented with acute ST-segment elevation myocardial infarction. Coronary imaging revealed an aberrant right coronary anatomy, ectatic coronary arteries, and significant stenosis. Based on previous literature and clinical presentation, this case highlights the potential role of neurofibromatosis in the pathogenesis of coronary artery disease.

Keywords: computed tomography; coronary angiography; coronary vessel anomaly; genetic disorders; genetics; myocardial infarction; neurofibromatosis; neurofibromatosis type 1; percutaneous coronary intervention; risk factor.