Exploring the role of autophagy in psoriasis pathogenesis: Insights into sustained inflammation and dysfunctional keratinocyte differentiation

Xinxin Wu; Jiankun Song; Ying Zhang; Le Kuai; Changya Liu; Xin Ma; Bin Li; Zhan Zhang; Ying Luo

doi:10.1016/j.intimp.2024.112244

Exploring the role of autophagy in psoriasis pathogenesis: Insights into sustained inflammation and dysfunctional keratinocyte differentiation

Int Immunopharmacol. 2024 Jun 30:135:112244. doi: 10.1016/j.intimp.2024.112244. Epub 2024 May 21.

Authors

Xinxin Wu¹, Jiankun Song¹, Ying Zhang¹, Le Kuai², Changya Liu³, Xin Ma⁴, Bin Li⁵, Zhan Zhang⁶, Ying Luo⁷

Affiliations

¹ Shanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai 200443, China.
² Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China.
³ Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China.
⁴ Shanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai 200443, China; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
⁵ Shanghai Skin Disease Hospital, Institute of Dermatology, School of Medicine, Tongji University, Shanghai 200443, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China.
⁶ Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: [email protected].
⁷ Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: [email protected].

PMID: 38776847
DOI: 10.1016/j.intimp.2024.112244

Abstract

Psoriasis is a common and prevalent chronic papulosquamous cutaneous disorder characterized by sustained inflammation, uncontrolled keratinocyte proliferation, dysfunctional differentiation, and angiogenesis. Autophagy, an intracellular catabolic process, can be induced in response to nutrient stress. It entails the degradation of cellular constituents through the lysosomal machinery, and its association with psoriasis has been well-documented. Nevertheless, there remains a notable dearth of research concerning the involvement of autophagy in the pathogenesis of psoriasis within human skin. This review provides a comprehensive overview of autophagy in psoriasis pathogenesis, focusing on its involvement in two key pathological manifestations: sustained inflammation and uncontrolled keratinocyte proliferation and differentiation. Additionally, it discusses potential avenues for disease management.

Keywords: Angiogenesis; Autophagy; Differentiation; Inflammation; Proliferation; Psoriasis.

Publication types

Review

MeSH terms

Animals
Autophagy*
Cell Differentiation*
Cell Proliferation
Humans
Inflammation* / immunology
Keratinocytes* / immunology
Keratinocytes* / pathology
Keratinocytes* / physiology
Psoriasis* / immunology
Psoriasis* / pathology
Skin / immunology
Skin / pathology