Influence of E-cadherin deficiency on the dendrite morphology of Langerhans cells

Britta Dorn; Cindy Ruhland; Stefanie Kunz; Stefan F Martin; Thilo Jakob

doi:10.1002/eji.202350797

Influence of E-cadherin deficiency on the dendrite morphology of Langerhans cells

Eur J Immunol. 2024 Sep;54(9):e2350797. doi: 10.1002/eji.202350797. Epub 2024 May 22.

Authors

Britta Dorn¹, Cindy Ruhland¹, Stefanie Kunz², Stefan F Martin², Thilo Jakob¹

Affiliations

¹ Department of Dermatology and Allergology, Experimental Dermatology and Allergy Research Group, University Medical Center Gießen, Justus Liebig University Gießen, Gießen, Germany.
² Allergy Research Group, Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.

PMID: 38778497
DOI: 10.1002/eji.202350797

Abstract

The expression of E-cadherin on Langerhans cells (LC) is required for adequate dendrite intercalation between epidermal keratinocytes. Upon disruption of epidermal homeostasis by tape stripping, E-cadherin competent LC extend dendrites reaching up to the epidermal surface, while E-cad deficient LC lack this ability.

Keywords: Adherens; Cadherin; Dendrites; Langerhans cells; Migration.

Publication types

Letter

MeSH terms

Animals
Cadherins* / genetics
Cadherins* / metabolism
Dendrites* / metabolism
Epidermis / metabolism
Keratinocytes / metabolism
Langerhans Cells* / immunology
Langerhans Cells* / metabolism
Mice
Mice, Knockout

Substances

Cadherins

Abstract

Publication types

MeSH terms

Substances

Grants and funding