Role of Phosphodiesterases in Biology and Pathology 2.0

Mauro Giorgi; Manuela Pellegrini; Mara Massimi

doi:10.3390/ijms25105339

Role of Phosphodiesterases in Biology and Pathology 2.0

Int J Mol Sci. 2024 May 14;25(10):5339. doi: 10.3390/ijms25105339.

Authors

Mauro Giorgi¹, Manuela Pellegrini², Mara Massimi³

Affiliations

¹ Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
² Institute of Biochemistry and Cell Biology, IBBC-CNR, Via E. Ramarini 32, 00015 Monterotondo (RM), Italy.
³ Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy.

Abstract

Phosphodiesterases (PDEs) are ubiquitous enzymes that hydrolyse cAMP and cGMP second messengers temporally, spatially, and integratedly according to their expression and compartmentalization inside the cell [...].

Publication types

Editorial
Introductory Journal Article

MeSH terms

Animals
Cyclic AMP / metabolism
Cyclic GMP / metabolism
Humans
Phosphoric Diester Hydrolases* / metabolism

Substances

Phosphoric Diester Hydrolases
Cyclic AMP
Cyclic GMP