Myocardial Mitochondrial Function Is Impaired in Cardiac Light-Chain Amyloidosis Compared to Transthyretin Amyloidosis

Fabian Voß; Elric Zweck; Rojda Ipek; Heinz-Peter Schultheiss; Michael Roden; Malte Kelm; Julia Szendroedi; Amin Polzin; Ralf Westenfeld; Daniel Scheiber

doi:10.1016/j.jchf.2024.03.012

Myocardial Mitochondrial Function Is Impaired in Cardiac Light-Chain Amyloidosis Compared to Transthyretin Amyloidosis

JACC Heart Fail. 2024 Oct;12(10):1778-1780. doi: 10.1016/j.jchf.2024.03.012. Epub 2024 May 22.

Authors

Affiliations

¹ University Hospital Düsseldorf, Düsseldorf, Germany.
² University Hospital Düsseldorf, Düsseldorf, Germany; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany; German Center for Diabetes Research, Partner Düsseldorf, Düsseldorf, Germany.
³ Institute for Cardiac Diagnostics and Therapy (IKDT), Berlin, Germany.
⁴ University Hospital Düsseldorf, Düsseldorf, Germany; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany; German Center for Diabetes Research, Partner Düsseldorf, Düsseldorf, Germany; CARID (Cardiovascular Research Institute Düsseldorf), Düsseldorf, Germany.
⁵ University Hospital Düsseldorf, Düsseldorf, Germany; CARID (Cardiovascular Research Institute Düsseldorf), Düsseldorf, Germany.
⁶ University Hospital Düsseldorf, Düsseldorf, Germany; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany; German Center for Diabetes Research, Partner Düsseldorf, Düsseldorf, Germany; CARID (Cardiovascular Research Institute Düsseldorf), Düsseldorf, Germany; University Hospital Heidelberg, Heidelberg, Germany; Institute for Diabetes and Cancer (IDC) and Joint Heidelberg-IDC Translational Diabetes Program, Helmholtz Center Munich, Neuherberg, Germany.
⁷ University Hospital Düsseldorf, Düsseldorf, Germany; Abiomed, Inc, Danvers, Massachusetts, USA.
⁸ University Hospital Düsseldorf, Düsseldorf, Germany. Electronic address: [email protected].

PMID: 38795111
DOI: 10.1016/j.jchf.2024.03.012

No abstract available

Publication types

Letter
Comparative Study

MeSH terms

Aged
Amyloid Neuropathies, Familial* / complications
Amyloid Neuropathies, Familial* / metabolism
Amyloid Neuropathies, Familial* / physiopathology
Cardiomyopathies* / etiology
Cardiomyopathies* / metabolism
Cardiomyopathies* / physiopathology
Female
Humans
Immunoglobulin Light-chain Amyloidosis
Male
Middle Aged
Mitochondria, Heart / metabolism
Myocardium / metabolism
Myocardium / pathology

Supplementary concepts

Amyloidosis, Hereditary, Transthyretin-Related