The hidden world of protein aggregation

Prog Mol Biol Transl Sci. 2024:206:473-494. doi: 10.1016/bs.pmbts.2024.03.014. Epub 2024 Apr 16.

Abstract

Though the book's journey into The Hidden World of Protein Aggregation has come to an end, the search for knowledge, the development of healthier lives, and the discovery of nature's mysteries continue, promising new horizons and discoveries yet to be discovered. The intricacies of protein misfolding and aggregation remain a mystery in cellular biology, despite advances made in unraveling them. In this chapter, we will summarize the specific conclusions from the previous chapters and explore the persistent obstacles and unanswered questions that motivate scientists to pursue exploration of protein misfolding and aggregation.

Keywords: Biotechnological approach; Functional amyloids; Protein aggregation; Therapeutic approach.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Protein Aggregates*
  • Protein Aggregation, Pathological / metabolism
  • Protein Folding
  • Proteins / chemistry
  • Proteins / metabolism

Substances

  • Protein Aggregates
  • Proteins