Acute Hepatitis in Children Due to Rat Hepatitis E Virus

Javier Caballero-Gómez; Sara Pereira; Irene Rivero-Calle; Ana B Perez; Isabel Viciana; María Casares-Jiménez; Lucia Rios-Muñoz; Antonio Rivero-Juarez; Antonio Aguilera; Antonio Rivero

doi:10.1016/j.jpeds.2024.114125

Acute Hepatitis in Children Due to Rat Hepatitis E Virus

J Pediatr. 2024 Oct:273:114125. doi: 10.1016/j.jpeds.2024.114125. Epub 2024 May 28.

Affiliations

¹ Unit of Infectious Diseases, Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Córdoba, Spain; Animal Health Department, Universidad de Córdoba, Córdoba, Spain; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.
² Microbiology Department, Hospital Clínico Universitario & University of Santiago de Compostela (USC)/IDIS, Santiago de Compostela, Spain.
³ Pediatrics Department, Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain; GENVIP Research Group, Instituto de Investigación Sanitaria de Santiago, Universidad de Santiago de Compostela, Galicia, Spain.
⁴ CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain; Clinical Microbiology Unit, Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain.
⁵ Microbiology Department, Málaga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of Málaga, Málaga, Spain.
⁶ Unit of Infectious Diseases, Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Córdoba, Spain; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.
⁷ Unit of Infectious Diseases, Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Córdoba, Spain.
⁸ Unit of Infectious Diseases, Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Córdoba, Spain; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: [email protected].

PMID: 38815747
DOI: 10.1016/j.jpeds.2024.114125

Abstract

Two of 11 children with acute hepatitis of unknown origin were found to have rat hepatitis E virus infection. This infection should be considered in the differential diagnosis of children with acute hepatitis of unknown origin.

Keywords: Public Health; Rocahepevirus; children; emerging; zoonoses.

Publication types

Case Reports

MeSH terms

Acute Disease
Adolescent
Animals
Child
Child, Preschool
Diagnosis, Differential
Female
Hepatitis E virus*
Hepatitis E* / diagnosis
Hepatitis, Viral, Animal / diagnosis
Hepatitis, Viral, Animal / virology
Humans
Infant
Male
Rats