A Systemic Review and Meta-analysis of Laparoscopic Surgery Versus Open Surgery for Gallbladder Cancer

Uday Karjol; Pavan Jonnada; Ali Zaid Anwar; Ajay Chandranath; Sushama Cheruku

doi:10.1007/s13193-022-01654-z

A Systemic Review and Meta-analysis of Laparoscopic Surgery Versus Open Surgery for Gallbladder Cancer

Indian J Surg Oncol. 2024 May;15(Suppl 2):218-225. doi: 10.1007/s13193-022-01654-z. Epub 2022 Nov 1.

Authors

Uday Karjol¹, Pavan Jonnada¹, Ali Zaid Anwar¹, Ajay Chandranath¹, Sushama Cheruku²

Affiliations

¹ Surgical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka India.
² Pathology, Am Path Laboratories, Hyderabad, Telangana India.

PMID: 38818007
PMCID: PMC11133283 (available on 2025-05-01)
DOI: 10.1007/s13193-022-01654-z

Abstract

Introduction: Laparoscopy in gallbladder cancer (GBC) has a possible role in staging, radical cure, and palliation in gallbladder cancer. However, a few studies have advocated the use of laparoscopic approach and concluded the safety of this approach. This present study was undertaken to determine the safety and feasibility between open and laparoscopic cholecystectomy in patients with the non-metastatic GBC.

Materials and methods: A systematic database search was performed in MEDLINE, Embase, and Google Scholar for relevant articles. As a result, a list of such studies, clinical trials, published in English up to May 2021, was obtained,14 studies were included and statistical analysis was conducted using RevMan software 5.3 (The Nordic Cochrane Centre).

Results: The 5-year survival rate was reported in 13 out of 14 studies (1388 patients), and all compared laparoscopic and open approach. There was no significant heterogeneity in between the studies (chi-square, 10.66; df, 12; I², 0%). There was significant higher overall survival in open group (389/850 vs 194/538 or 1.45, 95% CI (1.12-1.88), P value, 0.005). There was no significant difference in recurrence rate, operative time, blood loss, lymph node yield, and postoperative complication in between open and laparoscopic groups.

Conclusions: Our present study demonstrates that overall survival is significantly increased with open approach when compared with laparoscopic approach. There is no difference in recurrence rate, operative time, blood loss, lymph node yield, and postoperative complications between the open and laparoscopic cholecystectomy groups.

Keywords: Gallbladder cancer; Laparoscopy; Meta-analysis; Open.

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