Effects of caffeine on temporal perception in Rattus norvegicus

PLoS One. 2024 May 31;19(5):e0304608. doi: 10.1371/journal.pone.0304608. eCollection 2024.

Abstract

We report two studies that tested the effects of caffeine, the world's most widely used psychoactive drug, on temporal perception. We trained Wistar rats using the Bisection Procedure (Experiment 1) or the Stubbs' Procedure (Experiment 2) to discriminate between short and long light stimuli. Once training finished, we administered caffeine orally (0, 9.6, and 96.0 mg/kg for Experiment 1 and 0, 9.6, 19.2, and 38.4 mg/kg for Experiment 2) 15 minutes prior to testing. Relative to the control condition, the 9.6 mg/kg condition (Experiments 1 and 2) and the 19.2 mg/kg condition (Experiment 2) resulted in an increase in proportion of choosing the long response. Meanwhile, overall accuracy was not affected by any condition in both experiments. Taken together, these results are consistent with the notion that caffeine, at some doses, speeds up temporal perception. However, it is not clear why the effect disappears at higher doses.

MeSH terms

  • Animals
  • Caffeine* / pharmacology
  • Central Nervous System Stimulants / administration & dosage
  • Central Nervous System Stimulants / pharmacology
  • Dose-Response Relationship, Drug
  • Male
  • Rats
  • Rats, Wistar*
  • Time Perception* / drug effects

Substances

  • Caffeine
  • Central Nervous System Stimulants