A Novel Classification System of Renal Hilar Tumors for Surgical Guidance: Technique, Outcome, and Safety

Ann Surg Oncol. 2024 Sep;31(9):5794-5803. doi: 10.1245/s10434-024-15470-y. Epub 2024 Jun 1.

Abstract

Background: This study was designed to develop an innovative classification and guidance system for renal hilar tumors and to assess the safety and effectiveness of robot-assisted partial nephrectomy (RAPN) for managing such tumors.

Methods: A total of 179 patients undergoing RAPN for renal hilar tumors were retrospectively reviewed. A novel classification system with surgical techniques was introduced and the perioperative features, tumor characteristics, and the efficacy and safety of RAPN were compared within subgroups.

Results: We classified the tumors according to our novel system as follows: 131 Type I, 35 Type II, and 13 Type III. However, Type III had higher median R.E.N.A.L., PADUA, and ROADS scores compared with the others (all p < 0.001), indicating increased operative complexity and higher estimated blood loss [180.00 (115.00-215.00) ml]. Operative outcomes revealed significant disparities between Type III and the others, with longer operative times [165.00 (145.00-200.50) min], warm ischemia times [24.00 (21.50-30.50) min], tumor resection times [13.00 (12.00-15.50) min], and incision closure times [22.00 (20.00-23.50) min] (all p < 0.005). Postoperative outcomes also showed significant differences, with longer durations of drain removal (77.08 ± 18.16 h) and hospitalization for Type III [5.00 (5.00-6.00) d] (all p < 0.05). Additionally, Type I had a larger tumor diameter than the others (p = 0.009) and pT stage differed significantly between the subtypes (p = 0.020).

Conclusions: The novel renal hilar tumor classification system is capable of differentiating the surgical difficulty of RAPN and further offers personalized surgical steps tailored to each specific classification. It provides a meaningful tool for clinical practice.

Keywords: Hilar; Kidney cancer; R.E.N.A.L score; Renal lip; Robotic‐assisted laparoscopic partial nephrectomy.

MeSH terms

  • Adult
  • Aged
  • Blood Loss, Surgical / statistics & numerical data
  • Carcinoma, Renal Cell / classification
  • Carcinoma, Renal Cell / pathology
  • Carcinoma, Renal Cell / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Neoplasms* / classification
  • Kidney Neoplasms* / pathology
  • Kidney Neoplasms* / surgery
  • Length of Stay / statistics & numerical data
  • Male
  • Middle Aged
  • Nephrectomy* / methods
  • Operative Time
  • Postoperative Complications / classification
  • Postoperative Complications / etiology
  • Prognosis
  • Retrospective Studies
  • Robotic Surgical Procedures* / methods
  • Warm Ischemia