Triple threat: neutrophil ER stress, NETosis, airway inflammation escalation

Trends Cell Biol. 2024 Jul;34(7):527-530. doi: 10.1016/j.tcb.2024.04.004. Epub 2024 Jun 3.

Abstract

This report aims to propose the novel term 'neutrophil endoplasmic reticulum (ER) stress' (NERS). NERS explores the influence of neutrophil extracellular trap (NET) formation and exacerbation of respiratory ailments. This inquiry aims to advance comprehension in neutrophil biology and respiratory health.

Keywords: ER stress; ILIA; NERS; NETosis; infinity loop of inflammation amplification; inflammation; neutrophil.

MeSH terms

  • Animals
  • Endoplasmic Reticulum Stress*
  • Extracellular Traps* / metabolism
  • Humans
  • Inflammation* / metabolism
  • Inflammation* / pathology
  • Neutrophils* / metabolism