Asymmetric Total Synthesis of (+)-Lemnardosinane A

Org Lett. 2024 Jun 21;26(24):5105-5109. doi: 10.1021/acs.orglett.4c01384. Epub 2024 Jun 7.

Abstract

The asymmetric total synthesis of (+)-lemnardosinane A, a rare rearranged sesquiterpenoid, has been accomplished from (S)-carvone. Key features of the synthesis are the formation of a bicyclo[3.3.1]nonane skeleton using the intramolecular aldol reaction, the stereoselective introduction of an alkyne group, and the stereoselective formation of a tricyclic skeleton via intramolecular pinacol coupling.