Efficacy and Safety of Immune Checkpoint Blockade in Patients With Li-Fraumeni Syndrome

JCO Precis Oncol. 2024 Jun:8:e2400139. doi: 10.1200/PO.24.00139.

Michele Bottosso^{1

2}, Benjamin Verret^{1

3}, Olivier Caron⁴, Nadim Hamzaoui^{5

6}, Eric Pasmant^{5

6}, Francois-Xavier Danlos^{7

8

9}, Pascaline Boudou-Rouquette^{5

10}, Arunya Srikaran¹⁰, Hélène Blons¹¹, Valentina Guarneri^{2

12}, Sherene Loi^{13

14}, Fabrice André^{1

3}, Camille Tlemsani^{5

10}

¹ INSERM Unit U981, Gustave Roussy Cancer Campus, Villejuif, France.
² Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
³ Medical Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France.
⁴ Oncogenetic Department, Institut Gustave Roussy, Villejuif, France.
⁵ INSERM U1016, CNRS UMR8104, Université Paris Cité, CARPEM, Institut Cochin, Paris, France.
⁶ Department of Molecular Biology, Fédération de Génétique et Médecine Génomique, Cochin Hospital, Université Paris Cité, APHP Centre, Paris, France.
⁷ Drug Development Department, Gustave Roussy, Villejuif, France.
⁸ INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.
⁹ Faculté de Médecine, Université Paris Saclay, Gif-sur-Yvette, France.
¹⁰ Department of Medical Oncology, Cochin Hospital, Paris Cancer Institute CARPEM, Université Paris Cité, APHP Centre, Paris, France.
¹¹ Department of Molecular Biology, Fédération de Génétique et Médecine Génomique, European Geoges Pompidou Hospital, Université Paris Cité, APHP Centre, Paris, France.
¹² Medical Oncology 2, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy.
¹³ Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
¹⁴ The Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, Melbourne, VIC, Australia.

Abstract

A case series evaluating efficacy and safety of immune checkpoint blockade in Li-Fraumeni syndrome.