Linking IL-10 signaling with lipid metabolic programs in macrophages: dysregulated ceramide homeostasis drives colitis

Signal Transduct Target Ther. 2024 Jun 8;9(1):156. doi: 10.1038/s41392-024-01864-7.

Authors

Imke Atreya^{1

2}, Markus F Neurath^{3

4}

Affiliations

¹ Department of Medicine 1, University Hospital of Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
² Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.
³ Department of Medicine 1, University Hospital of Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. [email protected].
⁴ Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany. [email protected].

No abstract available

MeSH terms

Animals
Ceramides* / genetics
Ceramides* / metabolism
Colitis* / genetics
Colitis* / metabolism
Colitis* / pathology
Homeostasis / genetics
Humans
Interleukin-10* / genetics
Interleukin-10* / metabolism
Lipid Metabolism* / genetics
Macrophages* / immunology
Macrophages* / metabolism
Mice
Signal Transduction* / genetics

Substances

Ceramides
IL10 protein, mouse
Interleukin-10