Emotionality and self-regulation are crucial for positive development, especially during early adolescence when youths experience normative increases in behavioral problems and declines in prosociality. Using Latent Profile Analysis (LPA-a person-oriented technique to identify patterns of functioning within individuals), we identified youths' profiles based on dimensions of mother-reported negative emotionality (NE; anger/frustration, sadness/depressive mood), and Effortful Control (EC; attentional, activation and inhibitory control) and examined concurrent associations with self- and mother-reported aggressive and prosocial behaviors. We included a cross-national sample of 530 youths (M age =11.43; 49% males) from Colombia (17%), Italy (36%), and United States (47%). We identified four profiles: Adjusted (38%; low NE; high EC)-lowest aggression, highest prosociality; Average (34%; average NE and EC)-average aggression and prosociality; Emotional-regulated (20%; high NE; average EC)-average aggression and high prosociality; and Emotional-dysregulated (8%; high NE; low EC)-highest aggression, low prosociality. We highlight associations of different emotion-regulation patterns with specific behavioral responses in early adolescence.