Mast cells: The Janus of type 2 inflammation

Johanna Kotrba; Anne Dudeck

doi:10.1016/j.immuni.2024.05.011

Mast cells: The Janus of type 2 inflammation

Immunity. 2024 Jun 11;57(6):1182-1184. doi: 10.1016/j.immuni.2024.05.011.

Authors

Johanna Kotrba¹, Anne Dudeck²

Affiliations

¹ Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
² Institute for Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany; Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University, Magdeburg, Germany. Electronic address: [email protected].

PMID: 38865961
DOI: 10.1016/j.immuni.2024.05.011

Abstract

Mast cells (MCs) are effectors in type 2 immunity, well known for their detrimental roles in allergy. In this issue of Immunity, Alhallak et al. now identify a protective role of MCs against exacerbated immune responses mediated by prostaglandin E₂ (PGE₂)-driven soluble ST2.

Publication types

Comment

MeSH terms

Animals
Dinoprostone / immunology
Dinoprostone / metabolism
Humans
Inflammation* / immunology
Interleukin-1 Receptor-Like 1 Protein / immunology
Interleukin-1 Receptor-Like 1 Protein / metabolism
Mast Cells* / immunology
Mice
Receptors, Cell Surface / immunology
Receptors, Cell Surface / metabolism

Substances

Dinoprostone
Interleukin-1 Receptor-Like 1 Protein
Receptors, Cell Surface