CD8+ T cell tolerance: It doesn't translate

Katharine E Block; Stephen C Jameson

doi:10.1016/j.immuni.2024.05.014

CD8⁺ T cell tolerance: It doesn't translate

Immunity. 2024 Jun 11;57(6):1184-1186. doi: 10.1016/j.immuni.2024.05.014.

Authors

Katharine E Block¹, Stephen C Jameson²

Affiliations

¹ Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: [email protected].
² Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: [email protected].

PMID: 38865962
DOI: 10.1016/j.immuni.2024.05.014

Abstract

The mechanisms that make and break CD8⁺ T cell tolerance to self-antigens remain unclear. In this issue of Immunity, Van Der Byl et al. show that tolerant CD8⁺ T cells rapidly adopt an epigenetically and transcriptionally distinct cell state and exhibit impaired protein translation. Breaking tolerance requires both inflammation and increased antigen exposure to augment MYC expression and restore translation.

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MeSH terms

Animals
CD8-Positive T-Lymphocytes* / immunology
Epigenesis, Genetic / immunology
Humans
Immune Tolerance* / immunology
Mice
Protein Biosynthesis / immunology