Poking holes in the blood-brain barrier

Immunity. 2024 Jun 11;57(6):1192-1194. doi: 10.1016/j.immuni.2024.05.012.

Abstract

Bacterial lipopolysaccharide (LPS) is implicated in disrupting the blood-brain barrier (BBB). In a recent issue of Nature, Wei et al. now show that LPS activates the inflammatory caspases (4, 5, and 11) and gasdermin D (GSDMD) in brain endothelial cells, which triggers their pyroptotic cell death and disrupts the BBB.

Publication types

  • Comment

MeSH terms

  • Animals
  • Blood-Brain Barrier* / immunology
  • Blood-Brain Barrier* / metabolism
  • Caspases / metabolism
  • Endothelial Cells* / immunology
  • Endothelial Cells* / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Lipopolysaccharides* / immunology
  • Mice
  • Phosphate-Binding Proteins / metabolism
  • Pyroptosis

Substances

  • Lipopolysaccharides
  • Caspases
  • Intracellular Signaling Peptides and Proteins
  • Phosphate-Binding Proteins