Antitoxin nanoparticles: design considerations, functional mechanisms, and applications in toxin neutralization

Drug Discov Today. 2024 Aug;29(8):104060. doi: 10.1016/j.drudis.2024.104060. Epub 2024 Jun 10.

Abstract

The application of nanotechnology has significantly advanced the development of novel platforms that enhance disease treatment and diagnosis. A key innovation in this field is the creation of antitoxin nanoparticles (ATNs), designed to address toxin exposure. These precision-engineered nanosystems have unique physicochemical properties and selective binding capabilities, allowing them to effectively capture and neutralize toxins from various biological, chemical, and environmental sources. In this review, we thoroughly examine their therapeutic and diagnostic potential for managing toxin-related challenges. We also explore recent advancements and offer critical insights into the design and clinical implementation of ATNs.

Keywords: antitoxin nanoparticles; detoxification; nanotechnology; toxin diagnosis; toxin neutralization; toxins.

Publication types

  • Review

MeSH terms

  • Animals
  • Antitoxins / chemistry
  • Antitoxins / pharmacology
  • Antitoxins / therapeutic use
  • Drug Design
  • Humans
  • Nanoparticles*
  • Nanotechnology / methods

Substances

  • Antitoxins