Do oligodendrocytes regulate axonal glucose uptake and consumption?

Jessica L Fletcher; Kaylene M Young

doi:10.1016/j.tins.2024.06.001

Do oligodendrocytes regulate axonal glucose uptake and consumption?

Trends Neurosci. 2024 Aug;47(8):569-570. doi: 10.1016/j.tins.2024.06.001. Epub 2024 Jun 11.

Authors

Jessica L Fletcher¹, Kaylene M Young²

Affiliations

¹ Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool St, Hobart, TAS 7000, Australia.
² Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool St, Hobart, TAS 7000, Australia. Electronic address: [email protected].

PMID: 38866601
DOI: 10.1016/j.tins.2024.06.001

Abstract

Neurons have high energy demands. In a recent study, Looser et al. identified oligodendrocyte Kir4.1 as the activity-dependent driver of oligodendrocyte glycolysis that ensures that lactate is supplied to active neurons. Given that oligodendrocyte Kir4.1 also influenced axonal glucose consumption and uptake, oligodendrocytes may play a broader role in neuronal metabolic regulation.

Keywords: Kir4.1; conduction velocity; lactate; metabolism; potassium; sodium-calcium exchanger (NCX).

MeSH terms

Animals
Axons* / metabolism
Axons* / physiology
Glucose* / metabolism
Humans
Kcnj10 Channel
Neurons / metabolism
Oligodendroglia* / metabolism
Potassium Channels, Inwardly Rectifying / metabolism

Substances

Glucose
Potassium Channels, Inwardly Rectifying
Kcnj10 Channel