Tactical terminase: How a Salmonella prophage navigates oxidative stress

Sine Lo Svenningsen

doi:10.1016/j.chom.2024.05.010

Tactical terminase: How a Salmonella prophage navigates oxidative stress

Cell Host Microbe. 2024 Jun 12;32(6):781-783. doi: 10.1016/j.chom.2024.05.010.

Author

Sine Lo Svenningsen¹

Affiliation

¹ Department of Biology, University of Copenhagen, Copenhagen, Denmark. Electronic address: [email protected].

PMID: 38870894
DOI: 10.1016/j.chom.2024.05.010

Abstract

Stress-induced prophages commonly "jump ship" by inducing lysis via the host SOS response. In a recent work, Uppalapati et al. reports an alternate, stress-selective strategy. Instead of promoting lysis, the Salmonella Gifsy-1 prophage arrests growth specifically when the SOS response coincides with oxidative stress.

MeSH terms

Oxidative Stress*
Prophages* / genetics
Prophages* / physiology
SOS Response, Genetics
Salmonella / genetics
Salmonella / virology
Salmonella Phages / genetics
Salmonella Phages / physiology