Membrane Lipid Replacement for reconstituting mitochondrial function and moderating cancer-related fatigue, pain and other symptoms while counteracting the adverse effects of cancer cytotoxic therapy

Clin Exp Metastasis. 2024 Jun;41(3):199-217. doi: 10.1007/s10585-024-10290-6. Epub 2024 Jun 16.

Abstract

Cancer-related fatigue, pain, gastrointestinal and other symptoms are among the most familiar complaints in practically every type and stage of cancer, especially metastatic cancers. Such symptoms are also related to cancer oxidative stress and the damage instigated by cancer cytotoxic therapies to cellular membranes, especially mitochondrial membranes. Cancer cytotoxic therapies (chemotherapy and radiotherapy) often cause adverse symptoms and induce patients to terminate their anti-neoplastic regimens. Cancer-related fatigue, pain and other symptoms and the adverse effects of cancer cytotoxic therapies can be safely moderated with oral Membrane Lipid Replacement (MLR) glycerolphospholipids and mitochondrial cofactors, such as coenzyme Q10. MLR provides essential membrane lipids and precursors to maintain mitochondrial and other cellular membrane functions and reduces fatigue, pain, gastrointestinal, inflammation and other symptoms. In addition, patients with a variety of chronic symptoms benefit from MLR supplements, and MLR also has the ability to enhance the bioavailability of nutrients and slowly remove toxic, hydrophobic molecules from cells and tissues.

Keywords: Cancer cytotoxic therapy; Membrane phospholipids · Cancer treatment side effects; Mitochondria; Oxidative stress.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects
  • Cancer Pain / drug therapy
  • Cancer Pain / etiology
  • Fatigue* / chemically induced
  • Fatigue* / etiology
  • Humans
  • Membrane Lipids* / metabolism
  • Mitochondria* / drug effects
  • Neoplasms* / complications
  • Neoplasms* / drug therapy
  • Ubiquinone / analogs & derivatives
  • Ubiquinone / therapeutic use

Substances

  • Membrane Lipids
  • Antineoplastic Agents
  • coenzyme Q10
  • Ubiquinone