Isolation of two new cucurbitane-type triterpenoids from Kedrostis gijef

Nat Prod Res. 2024 Jun 17:1-9. doi: 10.1080/14786419.2024.2367236. Online ahead of print.

Abstract

Two new cucurbitane-type triterpenoids (2,3), together with two known compounds (1,4), were isolated from the aerial parts of Kedrostis gijef. The structure of all compounds was elucidated based on NMR, HRESIMS analyses, and by comparison with the literature. Additionally, the cytotoxic activity against HeLa, Caco-2, and SH-SY5Y cell lines was determined using MTT colorimetric assay.

Keywords: Kedrostis gijef; bryoamaride; cucurbitane-type triterpenoids; cytotoxicity; epimogroside.