Psathrosterols C-E, highly conjugated ergosterol derivatives from Psathyrella rogueiana with anti-inflammatory and immunosuppressive activity

Hua Guo; Quan-Ping Diao; Qian Han; Juan He; Zheng-Hong Pan; Tao Feng

doi:10.1016/j.fitote.2024.106084

Psathrosterols C-E, highly conjugated ergosterol derivatives from Psathyrella rogueiana with anti-inflammatory and immunosuppressive activity

Fitoterapia. 2024 Sep:177:106084. doi: 10.1016/j.fitote.2024.106084. Epub 2024 Jun 17.

Authors

Hua Guo¹, Quan-Ping Diao², Qian Han², Juan He³, Zheng-Hong Pan⁴, Tao Feng⁵

Affiliations

¹ Liaoning Key Laboratory of Development and Utilization for Natural Products Active Molecules, School of Chemistry and Life Science, Anshan Normal University, Anshan 114005, China. Electronic address: [email protected].
² Liaoning Key Laboratory of Development and Utilization for Natural Products Active Molecules, School of Chemistry and Life Science, Anshan Normal University, Anshan 114005, China.
³ Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, China.
⁴ Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, China. Electronic address: [email protected].
⁵ School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China. Electronic address: [email protected].

PMID: 38897251
DOI: 10.1016/j.fitote.2024.106084

Abstract

Three new ergosterols featuring with a highly conjugated ring system, psathrosterols C-E (1-3), have been isolated from the fungus Psathyrella rogueiana. The structures with the absolute configurations were elucidated by means of spectroscopic methods and single crystal X-ray diffraction. Compounds 1-3 exhibit inhibitory activity against NO production with IC₅₀ values ranging from 8.4 to 21.8 μM. Compound 1 inhibits the LPS-induced proliferation of B lymphocyte cells with an IC₅₀ value of 12.3 μM.

Keywords: Ergosterols; Immunosuppressive activity; NO production inhibition; Psathyrella rogueiana.

MeSH terms

Animals
Anti-Inflammatory Agents* / chemistry
Anti-Inflammatory Agents* / isolation & purification
Anti-Inflammatory Agents* / pharmacology
B-Lymphocytes / drug effects
Cell Proliferation / drug effects
China
Ergosterol* / analogs & derivatives
Ergosterol* / chemistry
Ergosterol* / isolation & purification
Ergosterol* / pharmacology
Immunosuppressive Agents* / chemistry
Immunosuppressive Agents* / isolation & purification
Immunosuppressive Agents* / pharmacology
Mice
Molecular Structure
Nitric Oxide
RAW 264.7 Cells

Substances

Ergosterol
Anti-Inflammatory Agents
Immunosuppressive Agents
Nitric Oxide