Striking an alliance between T cells and macrophages for enhanced cancer immunotherapy

Tessa Gargett; Lisa M Ebert

doi:10.1111/imcb.12799

Striking an alliance between T cells and macrophages for enhanced cancer immunotherapy

Immunol Cell Biol. 2024 Aug;102(7):535-537. doi: 10.1111/imcb.12799. Epub 2024 Jun 27.

Authors

Tessa Gargett^{1

2

3}, Lisa M Ebert^{1

2

3}

Affiliations

¹ Centre for Cancer Biology, SA Pathology and the University of South of Australia, Adelaide, SA, Australia.
² Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
³ Cancer Clinical Trials Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.

PMID: 38932646
DOI: 10.1111/imcb.12799

Abstract

A new study by Yamada-Hunter et al. reveals a novel approach to promote synergy-rather than antagonism-between macrophages and engineered T cells, leading to enhanced antitumor immunity.

Keywords: Antitumor immunity; engineered T cells; macrophages; synergy.

MeSH terms

Animals
Cell Communication / immunology
Humans
Immunotherapy* / methods
Immunotherapy, Adoptive / methods
Macrophages* / immunology
Neoplasms* / immunology
Neoplasms* / therapy
T-Lymphocytes* / immunology
Tumor Microenvironment / immunology