Abstract
Gluconeogenesis and palmitate incorporation into triacylglycerols and phosphatidylcholine were measured in isolated hepatocytes from control and ethanol-treated rats. Basal gluconeogenesis and its hormonal response decreased in hepatocytes from ethanol-treated animals; palmitate incorporation into triacylglycerols increased. In ethanol-treated rat liver, 45Ca2+ uptake and methylating capacity were reduced, and the hormonal response exhibited differences in binding parameters of insulin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium / metabolism
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Cell Membrane / metabolism
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Ethanol / pharmacology*
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Fatty Liver, Alcoholic / pathology*
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Glucagon / metabolism
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Gluconeogenesis
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Insulin / metabolism
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Liver / drug effects
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Liver / metabolism
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Liver / pathology*
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Methylation
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Palmitates / metabolism
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Phosphatidylcholines / metabolism
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Phospholipids / metabolism
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Rats
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Rats, Inbred Strains
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Triglycerides / metabolism
Substances
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Insulin
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Palmitates
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Phosphatidylcholines
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Phospholipids
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Triglycerides
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Ethanol
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Glucagon
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Calcium