Morphological Changes of Peri-Coronary Adipose Tissue Together with Elevated NLR in Acute Myocardial Infarction Patients in-Hospital

Lin Qi; Yanglei Li; Chengqi Kong; Siqi Li; Qinyue Wang; Hanqin Pan; Shuyi Zhang; Xinkai Qu; Ming Li; Mingxuan Li; Kailei Shi

doi:10.2147/JIR.S465605

Morphological Changes of Peri-Coronary Adipose Tissue Together with Elevated NLR in Acute Myocardial Infarction Patients in-Hospital

J Inflamm Res. 2024 Jun 25:17:4065-4076. doi: 10.2147/JIR.S465605. eCollection 2024.

Authors

Lin Qi^#¹, Yanglei Li^#², Chengqi Kong^#², Siqi Li², Qinyue Wang², Hanqin Pan², Shuyi Zhang³, Xinkai Qu², Ming Li¹, Mingxuan Li^{2

4}, Kailei Shi²

Affiliations

¹ Department of Computed Tomography, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
² Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
³ Department of Cardiac Care Unit, Tongren Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, People's Republic of China.
⁴ Department of Cardiology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.

^# Contributed equally.

Abstract

Background: Inflammation triggers atherosclerotic plaque rupture, leading to acute myocardial infarction (AMI). Following AMI, peri-coronary adipose tissue (PCAT) undergoes a transition from lipid-rich to hydrophilic characteristics due to vascular inflammation. This study investigates PCAT changes and neutrophil-to-lymphocyte ratio levels during AMI.

Patients and methods: 60 AMI patients undergoing coronary computed tomography angiography and angiography (Jan 2020-Jun 2022) were studied 60 age, gender, BMI-matched stable angina, and 60 non-coronary artery disease patients were included. Siemens VB20.0 measured PCAT-volume and fat attenuation index (FAI). Neutrophil-to-lymphocyte ratio levels were calculated by peripheral blood tests.

Results: The PCAT volume and PCAT-FAI gradually increased across the control, stable angina, and AMI groups, with a corresponding gradual rise in NLR. NLR exhibited weak positive correlation with PCAT-FAI (r=0.35) and PCAT-volume (r=0.24). Multivariable logistic regression identified increased PCAT-volume, PCAT-FAI and neutrophil-to-lymphocyte ratio as possible independent AMI risk factors. No significant PCAT-volume difference was observed between infarct-related artery (IRA) and non-IRA for all three coronary arteries. Only PCAT-FAI around IRA-LAD was higher than non-IRA-LAD (-74.84±6.93 HU vs -79.04±8.68 HU). PCAT-FAI around culprit vessels in AMI was higher than corresponding lesion related vessel in SA. PCAT-volume around narrowed non-IRA in AMI was higher than that of corresponding LRV in SA. PCAT-FAI of narrowed non-IRA-LADs and non-IRA-LCXs in AMI were elevated compared to LADs (-78.46±8.56HU vs -83.13±8.34 HU) and LCXs (-73.83±10.63 HU vs -81.38±7.88 HU) of lesion related vessel in stable angina.

Conclusion: We found an association between AMI and inflammation in the coronary perivascular adipose tissue and systemic inflammatory response.

Keywords: acute myocardial infarction; fat attenuation index; neutrophil-to-lymphocyte ratio; peri-coronary adipose tissue.

Grants and funding

This work was supported by the Science and Technology Commission of Shanghai Municipality (22ZR1422000), Center of geriatric coronary artery disease of Huadong hospital (LCXZ2205), and Shanghai Shenkang hospital development center (SHDC22023302).