Rapid Wane and Recovery of XBB Sublineage Neutralization After Sequential Omicron-based Vaccination in Solid Organ Transplant Recipients

Trevor S Johnston; Camille Hage; Aura T Abedon; Snigdha Panda; Jennifer L Alejo; Yolanda Eby; Dorry L Segev; Aaron A R Tobian; Andrea L Cox; William A Werbel; Andrew H Karaba

doi:10.1093/cid/ciae279

Rapid Wane and Recovery of XBB Sublineage Neutralization After Sequential Omicron-based Vaccination in Solid Organ Transplant Recipients

Clin Infect Dis. 2024 Sep 26;79(3):652-655. doi: 10.1093/cid/ciae279.

Authors

Affiliations

¹ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
² Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
³ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁴ Department of Surgery, NYU Grossman School of Medicine, New York, New York, USA.
⁵ W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
⁶ Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Abstract

Durability of variant neutralization in solid organ transplant recipients following Omicron-containing boosters is unknown. We report wane in XBB.1.5 neutralization by 3 months following a first bivalent booster, improved by a second booster; hybrid immunity improved peak, and duration of neutralization. Boosting at 3 to 6 months appears necessary to maintain neutralization.

Keywords: COVID-19; SARS-CoV-2; immunocompromised host; vaccines.

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MeSH terms

2019-nCoV Vaccine mRNA-1273 / immunology
Adult
Aged
Antibodies, Neutralizing* / blood
Antibodies, Neutralizing* / immunology
Antibodies, Viral* / blood
COVID-19 Vaccines* / administration & dosage
COVID-19 Vaccines* / immunology
COVID-19* / immunology
COVID-19* / prevention & control
Female
Humans
Immunization, Secondary*
Male
Middle Aged
Organ Transplantation* / adverse effects
SARS-CoV-2* / immunology
Transplant Recipients*
Vaccination

Rapid Wane and Recovery of XBB Sublineage Neutralization After Sequential Omicron-based Vaccination in Solid Organ Transplant Recipients

Authors

Affiliations

Abstract

MeSH terms

Substances

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