Abstract
Polyclonal anti-idiotypic antibodies against monoclonal antibodies with specificity for RT1-encoded antigens were induced in syngeneic, allogeneic, and xenogeneic hosts. The immune response to the idiotypic determinants on monoclonal antibodies was T-cell-dependent. The anti-idiotypic antibodies, independent of whether they were induced in syngeneic, allogeneic, or xenogeneic (after proper absorption) hosts, showed an exquisite specificity for the monoclonal antibody used for the induction. No cross-reactivity with other monoclonal antibodies could be observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Anti-Idiotypic / analysis
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Antibodies, Anti-Idiotypic / biosynthesis*
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Antibodies, Anti-Idiotypic / physiology
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Antibodies, Monoclonal / administration & dosage*
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Antibodies, Monoclonal / immunology
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Antibody Specificity
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Histocompatibility Antigens / genetics
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Histocompatibility Antigens / immunology*
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Immunization / methods
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Immunoglobulin Idiotypes / immunology*
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Immunosorbent Techniques
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Rabbits
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Rats
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Rats, Inbred BN
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Rats, Inbred Lew
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Rats, Mutant Strains
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T-Lymphocytes / immunology
Substances
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Antibodies, Anti-Idiotypic
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Antibodies, Monoclonal
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Histocompatibility Antigens
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Immunoglobulin Idiotypes
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histocompatibility antigens RT, rat