Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy

Imkongyanger; Kikoleho Richa; Tsenbeni N Lotha; Ketiyala Ao; Lemzila Rudithongru; Vevosa Nakro; Vimha Ritse; Nima D Namsa; Pranay Punj Pankaj; Upasana Bora Sinha; Latonglila Jamir

doi:10.2174/0118715303287962240621053459

Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy

Endocr Metab Immune Disord Drug Targets. 2024 Jul 2. doi: 10.2174/0118715303287962240621053459. Online ahead of print.

Authors

Affiliations

¹ Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy.
² Department of Biotechnology, St. Joseph University, Chumoukedima, 797115, Nagaland, India.
³ Department of Environmental Science, Nagaland University, Lumami, 798627, Nagaland, India.
⁴ Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, 784028, Assam, India.
⁵ Department of Zoology, Nagaland University, Lumami, 798627, Nagaland, India.
⁶ Department of Chemistry, Nagaland University, Lumami, 798627, Nagaland, India.

PMID: 38956919
DOI: 10.2174/0118715303287962240621053459

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) represents a significant and pressing worldwide health concern, necessitating the quest for enhanced antidiabetic pharmaceuticals. Guanidine derivatives, notably metformin and buformin, have emerged as pivotal therapeutic agents for T2DM management.

Aims: The present study introduces an efficient one-pot synthesis method for the production of symmetrical guanidine compounds.

Methods: This synthesis involves the reaction of isothiocyanates with secondary amines, employing an environmentally friendly and recyclable reagent, tetrabutylphosphonium tribromide (TBPTB).

Results: A comprehensive assessment of the biological activity of the synthesized guanidine compounds, specifically in the context of T2DM, has been rigorously conducted.

Conclusion: Additionally, computational analyses have unveiled their substantial potential as promising antidiabetic agents. Results highlight the relevance of these compounds in the ongoing pursuit of novel therapeutic solutions for T2DM.</p>.

Keywords: Guanidine; Type 2 diabetes mellitus; antidiabetic agents; compounds; computational studies; tetrabutylphosphonium tribromide; therapeutics..