Androgen receptor post-translational modifications and their implications for pathology

Inés Montoya-Novoa; José Luis Gardeazábal-Torbado; Andrea Alegre-Martí; Pablo Fuentes-Prior; Eva Estébanez-Perpiñá

doi:10.1042/BST20231082

Androgen receptor post-translational modifications and their implications for pathology

Biochem Soc Trans. 2024 Aug 28;52(4):1673-1694. doi: 10.1042/BST20231082.

Authors

Inés Montoya-Novoa^#^{1

2}, José Luis Gardeazábal-Torbado^#^{1

2}, Andrea Alegre-Martí^{1

2}, Pablo Fuentes-Prior^{1

2}, Eva Estébanez-Perpiñá^{1

2}

Affiliations

¹ Structural Biology of Nuclear Receptors, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona (UB), 08028 Barcelona, Spain.
² Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona (UB), 08028 Barcelona, Spain.

^# Contributed equally.

PMID: 38958586
DOI: 10.1042/BST20231082

Abstract

A major mechanism to modulate the biological activities of the androgen receptor (AR) involves a growing number of post-translational modifications (PTMs). In this review we summarise the current knowledge on the structural and functional impact of PTMs that affect this major transcription factor. Next, we discuss the cross-talk between these different PTMs and the presence of clusters of modified residues in the AR protein. Finally, we discuss the implications of these covalent modifications for the aetiology of diseases such as spinal and bulbar muscular atrophy (Kennedy's disease) and prostate cancer, and the perspectives for pharmacological intervention.

Keywords: androgen insensitivity syndrome; androgen receptor; crystallography; post translational modification; prostate cancer; spinal and bulbar muscular atrophy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bulbo-Spinal Atrophy, X-Linked / metabolism
Humans
Male
Prostatic Neoplasms* / metabolism
Prostatic Neoplasms* / pathology
Protein Processing, Post-Translational*
Receptors, Androgen* / metabolism

Substances

Receptors, Androgen