Remission of hypersensitivity pneumonitis after allogeneic hematopoietic stem cell transplantation

Respir Investig. 2024 Sep;62(5):759-761. doi: 10.1016/j.resinv.2024.06.007. Epub 2024 Jul 2.

Abstract

A 50-year-old man was diagnosed with hypersensitivity pneumonitis caused by the environment of his bar owing to worsening symptoms, laboratory test results, and computed tomography images after an environmental inhalation challenge test. His hypersensitivity pneumonitis exacerbated despite receiving prednisolone 20 mg/day. The patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen-matched unrelated donor for myelodysplastic syndrome. No exacerbation of hypersensitivity pneumonitis was observed after HSCT. An environmental inhalation challenge test involving exposure to his bar confirmed the remission of hypersensitivity pneumonitis after HSCT. This case demonstrates that hypersensitivity pneumonitis can be remitted by HSCT.

Keywords: Allogeneic hematopoietic stem cell transplantation; Environmental inhalation challenge test; Hypersensitivity pneumonitis; Myelodysplastic syndrome.

Publication types

  • Case Reports

MeSH terms

  • Alveolitis, Extrinsic Allergic* / diagnosis
  • Alveolitis, Extrinsic Allergic* / etiology
  • Alveolitis, Extrinsic Allergic* / therapy
  • Hematopoietic Stem Cell Transplantation* / adverse effects
  • Humans
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes* / therapy
  • Prednisolone / administration & dosage
  • Remission Induction
  • Tomography, X-Ray Computed
  • Transplantation, Homologous*

Substances

  • Prednisolone