Coping with the experience of frustration throughout life: Sex- and age-specific effects of early life stress on the susceptibility to reward devaluation

Neuroscience. 2024 Aug 16:553:160-171. doi: 10.1016/j.neuroscience.2024.06.020. Epub 2024 Jul 2.

Abstract

Early life stress may lead to lifelong impairments in psychophysiological functions, including emotional and reward systems. Unpredicted decrease in reward magnitude generates a negative emotional state (frustration) that may be involved with susceptibility to psychiatric disorders. We evaluated, in adolescents and adult rats of both sexes, whether maternal separation (MS) alters the ability to cope with an unexpected reduction of reward later in life. Litters of Wistar rats were divided into controls (non handled - NH) or subjected to MS. Animals were trained to find sugary cereal pellets; later the amount was reduced. Increased latency to reach the reward-associated area indicates higher inability to regulate frustration. The dorsal hippocampus (dHC) and basolateral amygdala (BLA) were evaluated for protein levels of NMDA receptor subunits (GluN2A/GluN2B), synaptophysin, PSD95, SNAP-25 and CRF1. We found that adult MS males had greater vulnerability to reward reduction, together with decreased GluN2A and increased GluN2B immunocontent in the dHC. MS females and adolescents did not differ from controls. We concluded that MS enhances the response to frustration in adult males. The change in the ratio of GluN2A and GluN2B subunits in dHC could be related to a stronger, more difficult to update memory of the aversive experience.

Keywords: Basolateral amygdala; Emotional memory; Hippocampus; Maternal separation; Psychiatric disorders; Synaptic plasticity.

MeSH terms

  • Adaptation, Psychological / physiology
  • Age Factors
  • Animals
  • Basolateral Nuclear Complex / metabolism
  • Female
  • Frustration
  • Hippocampus / metabolism
  • Male
  • Maternal Deprivation*
  • Rats
  • Rats, Wistar*
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Reward*
  • Sex Characteristics
  • Stress, Psychological* / metabolism
  • Stress, Psychological* / physiopathology
  • Stress, Psychological* / psychology

Substances

  • Receptors, N-Methyl-D-Aspartate
  • NR2B NMDA receptor