A new path to migraine

Science. 2024 Jul 5;385(6704):28-29. doi: 10.1126/science.adq3498. Epub 2024 Jul 4.

Andrew F Russo^{1

2}, Jeffrey J Iliff^{3

4

5}

¹ Department of Molecular Physiology and Biophysics, Department of Neurology, University of Iowa, Iowa City, IA, USA.
² Veterans Affairs Healthcare System, Iowa City, IA, USA.
³ Veterans Integrated Services Network (VISN 20) Northwest Mental Illness Research, Education, and Clinical Center, VA Puget Sound Healthcare System, Seattle, WA, USA.
⁴ Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
⁵ Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.

Abstract

Cerebrospinal fluid influx directly activates trigeminal neurons in a migraine model.