Histone demethylation tones down leukemia through innate immunity

Sci Immunol. 2024 Jul 5;9(97):eadr2967. doi: 10.1126/sciimmunol.adr2967. Epub 2024 Jul 5.

Authors

Andre Monteleone^{1

2}, Gabriel K Griffin^{2

3}

Affiliations

¹ Albert Einstein College of Medicine, Bronx, NY, USA.
² Dana-Farber Cancer Institute, Boston, MA, USA.
³ Broad Institute of MIT and Harvard, Cambridge, MA, USA.

PMID: 38968339
DOI: 10.1126/sciimmunol.adr2967

Abstract

Histone demethylation by PHF8 initiates innate immune signaling in acute myeloid leukemia, elucidating a novel therapeutic strategy.

MeSH terms

Animals
Demethylation
Histone Demethylases / immunology
Histone Demethylases / metabolism
Histones* / immunology
Histones* / metabolism
Humans
Immunity, Innate* / immunology
Leukemia, Myeloid, Acute* / genetics
Leukemia, Myeloid, Acute* / immunology
Signal Transduction / immunology
Transcription Factors / immunology

Substances

Histones
Transcription Factors
Histone Demethylases