A patient with axial spondylarthritis who experienced pancytopenia while receiving anti-TNF therapy

Clin Rheumatol. 2024 Aug;43(8):2701-2705. doi: 10.1007/s10067-024-07054-8. Epub 2024 Jul 6.

Abstract

Aplastic anemia is a rare and heterogeneous disease that causes pancytopenia and aplasia of the bone marrow. It is characterized by a failure of hematopoiesis. It is believed that approximately 65% of cases of acquired aplastic anemia are idiopathic. In a subset of cases, a drug or infection is the cause of bone marrow failure. This case report presents a 38-year-old patient with axial spondylarthritis who developed pancytopenia and was diagnosed with aplastic anemia during anti-TNF-α treatment.

Keywords: Anti-TNF; Aplastic anemia; Etanercept; Thrombocytopenia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Anemia, Aplastic* / chemically induced
  • Antirheumatic Agents / adverse effects
  • Axial Spondyloarthritis / chemically induced
  • Humans
  • Infliximab / adverse effects
  • Infliximab / therapeutic use
  • Male
  • Pancytopenia* / chemically induced
  • Spondylarthritis / complications
  • Spondylarthritis / drug therapy
  • Tumor Necrosis Factor-alpha* / antagonists & inhibitors

Substances

  • Tumor Necrosis Factor-alpha
  • Antirheumatic Agents
  • Infliximab