Unraveling the function of FGF signaling in human hypoblast specialization

Hao Wu; Jinglei Zhai; Hongmei Wang

doi:10.1016/j.stem.2024.06.010

Unraveling the function of FGF signaling in human hypoblast specialization

Cell Stem Cell. 2024 Jul 5;31(7):945-946. doi: 10.1016/j.stem.2024.06.010.

Authors

Hao Wu¹, Jinglei Zhai¹, Hongmei Wang²

Affiliations

¹ Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
² Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: [email protected].

PMID: 38971145
DOI: 10.1016/j.stem.2024.06.010

Abstract

Dattani et al.¹ developed a method for inducing hypoblast-like cells from human naive pluripotent stem cells. They elucidated the requirement for FGF signaling in human hypoblast specialization at a specific time window, which was previously controversial.

MeSH terms

Cell Differentiation
Fibroblast Growth Factors* / metabolism
Humans
Pluripotent Stem Cells / cytology
Pluripotent Stem Cells / metabolism
Signal Transduction*

Substances

Fibroblast Growth Factors