Outcomes of Concomitant Cardiac Surgical Procedures Performed During Pediatric Lung Transplantation in the United States

Lung. 2024 Aug;202(4):459-464. doi: 10.1007/s00408-024-00718-x. Epub 2024 Jul 6.

Abstract

Data on concomitant cardiac surgery (CCS) performed during pediatric lung transplantation (LTx) is limited. Therefore, we conducted a multi-institutional analysis to identify the incidence and outcomes of CCS in pediatric (< 18 years) LTx recipients by merging data (2004-2023) from the United Network for Organ Sharing (UNOS) and Pediatric Health Information System (PHIS) databases. Of the total of 596 pediatric LTx recipients, 87 (15%) underwent CCS. The majority of these cardiac surgeries were atrial septal defect (ASD) closure (90%) followed by aortic arch/descending aortic repair (3%), atrial repair (3%), ventricular septal defect closure (2%), patent ductus arteriosus ligation (2%), and tricuspid valve repair (2%). The median age at LTx was 3 years (IQR: 0-12). Pulmonary hypertension (PHT) was the predominant indication for LTx (54%). Survival to discharge was 94% and 5-years survival was 64%. Our findings indicate CCS in children undergoing LTx has acceptable outcomes.

Keywords: Atrial septal defect; Cardiac surgery; Outcomes; Pediatric lung transplantation; Pulmonary hypertension.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Cardiac Surgical Procedures* / methods
  • Child
  • Child, Preschool
  • Databases, Factual
  • Female
  • Heart Defects, Congenital / complications
  • Heart Defects, Congenital / surgery
  • Humans
  • Hypertension, Pulmonary / surgery
  • Incidence
  • Infant
  • Infant, Newborn
  • Lung Transplantation* / statistics & numerical data
  • Male
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome
  • United States / epidemiology