Ceramides in the central control of metabolism

Miguel López; Carlos Diéguez; Manuel Tena-Sempere; Ismael González-García

doi:10.1016/j.tem.2024.06.007

Ceramides in the central control of metabolism

Trends Endocrinol Metab. 2024 Jul 6:S1043-2760(24)00167-X. doi: 10.1016/j.tem.2024.06.007. Online ahead of print.

Authors

Miguel López¹, Carlos Diéguez², Manuel Tena-Sempere³, Ismael González-García⁴

Affiliations

¹ Department of Physiology, CiMUS, University of Santiago de Compostela, Santiago de Compostela, 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain. Electronic address: [email protected].
² Department of Physiology, CiMUS, University of Santiago de Compostela, Santiago de Compostela, 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain.
³ CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain; Instituto Maimonides de Investigación Biomédica de Córdoba, Córdoba, Spain; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba 14004, Spain.
⁴ Department of Physiology, CiMUS, University of Santiago de Compostela, Santiago de Compostela, 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain. Electronic address: [email protected].

PMID: 38972782
DOI: 10.1016/j.tem.2024.06.007

Abstract

Central ceramides regulate energy metabolism by impacting hypothalamic neurons. This allows ceramides to integrate endocrine signals - such as leptin, ghrelin, thyroid hormones, or estradiol - and to modulate the central control of puberty. In this forum article we discuss recent evidence suggesting that specific ceramide species and neuronal populations are involved in these effects.

Keywords: ceramides; food intake; glucose metabolism; hypothalamus; thermogenesis.