Therapeutic Myths in Solid Organ Transplantation Infectious Diseases

Kellie J Goodlet; Erin K McCreary; Michael D Nailor; Darina Barnes; Marissa M Brokhof; Sarah Bova; Evan Clemens; Beth Kelly; Alicia Lichvar; Dawn M Pluckrose; Bryant B Summers; Kristen R Szempruch; Stephanie Tchen

doi:10.1093/ofid/ofae342

Therapeutic Myths in Solid Organ Transplantation Infectious Diseases

Open Forum Infect Dis. 2024 Jun 15;11(7):ofae342. doi: 10.1093/ofid/ofae342. eCollection 2024 Jul.

Authors

Affiliations

¹ Department of Pharmacy Practice, Midwestern University, Glendale, Arizona, USA.
² Department of Medicine, Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
³ Department of Pharmacy Services, St Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
⁴ Department of Pharmacy, Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, California, USA.
⁵ Department of Pharmacy, Rush University Medical Center, Chicago, Illinois, USA.
⁶ Department of Pharmacy, University of Maryland Medical Center, Baltimore, Maryland, USA.
⁷ Department of Pharmacy, University of Washington Medical Center, Seattle, Washington, USA.
⁸ Department of Pharmacy, Indiana University Health, Indianapolis, Indiana, USA.
⁹ Center for Transplantation, UC San Diego Health, San Diego, California, USA.
¹⁰ Department of Pharmacy, Tufts Medical Center, Boston, Massachusetts, USA.
¹¹ Comprehensive Transplant Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
¹² Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, North Carolina, USA.
¹³ Department of Pharmacy, Froedtert Hospital, Milwaukee, Wisconsin, USA.

Abstract

Infection management in solid organ transplantation poses unique challenges, with a diverse array of potential pathogens and associated antimicrobial therapies. With limited high-quality randomized clinical trials to direct optimal care, therapeutic "myths" may propagate and contribute to suboptimal or excessive antimicrobial use. We discuss 6 therapeutic myths with particular relevance to solid organ transplantation and provide recommendations for infectious diseases clinicians involved in the care of this high-risk population.

Keywords: BK virus; asymptomatic bacteriuria; dental prophylaxis; ganciclovir; trimethoprim-sulfamethoxazole; vaccination.