Novel NLRP3 inflammasome inhibitors INF150 and INF195 attenuate isoproterenol-induced hypertrophy in H9c2 rat cardiac myoblast

Vascul Pharmacol. 2024 Jun:155:107321. doi: 10.1016/j.vph.2024.107321.

Authors

Magalì Giordano¹, Chiara Rubeo¹, Tommaso Angelone², Giovanna Gambarotta³, Stefano Comità¹, Francesco Fedele⁴, Massimo Bertinaria⁵, Pasquale Pagliaro¹, Claudia Penna¹

Affiliations

¹ Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, 10043 Torino, TO, Italy.
² Laboratory of Cellular and Molecular Cardiovascular Pathophysiology, Department of Biology, E. and E.S. (Di.B.E.S.T.), University of Calabria, 87036 Rende (CS), Italy.
³ Department of Clinical and Biological Sciences Neuroscience Institute Cavalieri Ottolenghi, University of Torino, Torino, Italy.
⁴ Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.
⁵ Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy.

PMID: 38985589
DOI: 10.1016/j.vph.2024.107321

No abstract available

MeSH terms

Animals
Cardiomegaly / chemically induced
Cardiomegaly / metabolism
Cardiomegaly / pathology
Cardiomegaly / prevention & control
Cell Line
Inflammasomes* / antagonists & inhibitors
Inflammasomes* / drug effects
Inflammasomes* / metabolism
Isoproterenol*
Myoblasts, Cardiac / drug effects
Myoblasts, Cardiac / metabolism
Myoblasts, Cardiac / pathology
Myocytes, Cardiac / drug effects
Myocytes, Cardiac / metabolism
Myocytes, Cardiac / pathology
NLR Family, Pyrin Domain-Containing 3 Protein* / antagonists & inhibitors
NLR Family, Pyrin Domain-Containing 3 Protein* / metabolism
Rats

Substances

NLR Family, Pyrin Domain-Containing 3 Protein
Isoproterenol
Inflammasomes
Nlrp3 protein, rat