RIPK1: Inflamed if you do, inflamed if you don't

Nicholas W Hubbard; Andrew Oberst

doi:10.1016/j.immuni.2024.06.002

RIPK1: Inflamed if you do, inflamed if you don't

Immunity. 2024 Jul 9;57(7):1443-1445. doi: 10.1016/j.immuni.2024.06.002.

Authors

Nicholas W Hubbard¹, Andrew Oberst²

Affiliations

¹ Department of Human Genetics, University of Utah, Salt Lake City, UT, USA.
² Department of Immunology, University of Washington, Seattle, WA, USA. Electronic address: [email protected].

PMID: 38986436
DOI: 10.1016/j.immuni.2024.06.002

Abstract

RIPK1 is known as a driver of cell death and inflammation. In this issue of Immunity, Imai et al. and Mannion et al. find that these same processes are also induced by RIPK1 inactivation and highlight the therapeutic potential of RIPK1 elimination.

Publication types

Comment

MeSH terms

Animals
Cell Death / immunology
Humans
Inflammation* / immunology
Mice
Receptor-Interacting Protein Serine-Threonine Kinases* / metabolism

Substances

Receptor-Interacting Protein Serine-Threonine Kinases
RIPK1 protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding