Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India

Clin Infect Dis. 2024 Oct 15;79(4):1034-1038. doi: 10.1093/cid/ciae367.

Abstract

In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.1% death, 6.8% loss to follow-up) over a median 12-month follow-up period. Age, male sex, low education, nutritional status, and alcohol use were predictors of unfavorable outcomes.

Keywords: epidemiology; prospective cohort; risk factors; treatment outcome; tuberculosis.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antitubercular Agents* / therapeutic use
  • Cohort Studies
  • Female
  • Humans
  • India / epidemiology
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Treatment Failure
  • Treatment Outcome
  • Tuberculosis, Pulmonary* / drug therapy
  • Tuberculosis, Pulmonary* / epidemiology
  • Tuberculosis, Pulmonary* / mortality
  • Young Adult

Substances

  • Antitubercular Agents